MetaboliX^® Plus

Product Information

Our human body is made up of trillions of cells. They are the basic building blocks of life. Cells have specific tasks to perform and they work together to enable the body to meet its basic needs. These cellular processes require energy to function. However, as we age, cellular energy production in our body decreases¹.

NAD+ THE MOLECULE OF YOUTH

Nicotinamide adenine dinucleotide (NAD+) is a co-enzyme that is present naturally in every cell of our body and is essential to life. It is known as the molecule of youth due to its role in cellular energy production and its ability to regulate the genes of aging¹. Unfortunately, as we grow older, the NAD+ levels in our body decline¹.
MetaboliX^® Plus contains nicotinamide which is a precursor of NAD+ to boost the NAD+ cellular levels in the body. Daily supplementation of MetaboliX^® Plus combats the ravages of aging!

SUPPORT ENERGY PRODUCTION

Mitochondria are powerhouses of our cells. They are empowered by NAD+ in the production of cellular energy for the sustenance of life. As the level of NAD+ declines with age, mitochondria function is impaired which results in reduced amount of surviving healthy mitochondria². This vicious cycle of the depletion of mitochondria which results in metabolic energy deficiency is evident in the physical symptoms of aging such as chronic fatigue and weakness. NAD+ is crucial in the maintenance of functional mitochondria in preserving cellular energy reserve to ensure the body to be in a constant state of health.

“TURN OFF” AGING GENES

Sirtuins are enzymes that have the ability to regulate the genes of aging³. These enzymes are dependent on NAD+ for their function as NAD+ directly activates them to switch off genes that promote aging^4,5. Therefore, boosting the level of NAD+ is intimately related to longevity.

DNA CELL REPAIR

Poly-ADP-ribose polymerase-1 (PARP-1) is an enzyme that detects DNA damage and initiates DNA repair⁶. The function of PARP-1 is important as the accumulated replication of damaged DNA would lead to progressive functional decline in many tissues in our body which contributes to the process of aging⁶. For PARP-1 to exert its effect, it requires NAD+ as its sole substrate^6,7. Thus, replenishment of NAD+ via supplementation is important in the prevention of damaged DNA replication and the initiation of DNA repair to protect cellular integrity⁷. In addition, blueberry extract is a potent antioxidant which protects cells and deters cell damage as well, complementing the actions of NAD+.

REDUCE INFLAMMATION AND JOINT PAIN

As we age, we are more inclined to get aches and pains caused by inflammation. Boswellic acids have anti-inflammatory benefit as it interferes with several protein mediators which are part of the inflammatory cascade⁸. Particularly, in the inhibition of 5-lipoxygenase enzyme that is responsible for the synthesis of prostaglandin E2. which is one of the inflammatory mediators that plays a decisive role in the inflammatory process⁹. By blocking this enzyme effectively, boswellic acids are able to reduce inflammatory reaction and relief joint pains^9,10 caused by mild osteoarthritis.

Ingredients

Serving Size: 1-2 capsules
Servings Per Container: Up to 60
Amount Per Capsule:

Directions

How to use

Take 1-2 capsules every morning with or without food or as recommended by your physician.

Storage

Store in cool, dry place. Keep out of reach of children. Use only if bottle is sealed.

Precautions

Do not take MetaboliX^® Plus if you are pregnant, breastfeeding, trying to conceive or under 18 years of age.
If you have any medical conditions, please consult your physician prior to use.

Science

1. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471.
2. Croteau D, Fang E, Nilsen H, Bohr V. NAD+ in DNA repair and mitochondrial maintenance. Cell Cycle. 2017;16(6):491-492.
3. Guarente L. Linking DNA Damage, NAD+/SIRT1, and Aging. Cell Metabolism. 2014;20(5):706-707.
4. Belenky P, Racette F, Bogan K, McClure J, Smith J, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+. Cell. 2007;129(3):473-484.
5. Longo V, Kennedy B. Sirtuins in Aging and Age-Related Disease. Cell. 2006;126(2):257-268.
6. Javle M, Curtin N. The role of PARP in DNA repair and its therapeutic exploitation. British Journal of Cancer. 2011;105(8):1114-1122.
7. Surjana D, Halliday G, Damian D. Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair. Journal of Nucleic Acids. 2010;2010:1-13.
8. Iram F, Khan S, Husain A. Phytochemistry and potential therapeutic actions of Boswellic acids: A mini-review. Asian Pacific Journal of Tropical Biomedicine. 2017;7(6):513-523.
9. Rossi A, Pergola C, Koeberle A, Hoffmann M, Dehm F, Bramanti P et al. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages. British Journal of Pharmacology. 2010;161(3):555-570.
10. Ammon H. Boswellic Acids in Chronic Inflammatory Diseases. Planta Medica. 2006;72(12):1100-1116.

FAQ

Who is MetaboliX^® Plus suitable for?

MetaboliX^® Plus is most suitable for men and women who:
– are in their 30s or older
– are experiencing pain or discomfort in their joints even though they have not sustained any injury to them
– wish to boost their energy levels to combat end-of-day fatigue
– wish to maintain an active lifestyle

What is nicotinamide?

Nicotinamide is a form of vitamin B3. It is the primary precursor of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in cellular repair and energy production.

What is the difference between RestoriX^® and MetaboliX^® Plus?

Although both products contain nicotinamide which is essential for cellular repair and energy production, MetaboliX^® Plus has the added ingredient of boswellic acids for people who suffer from joint discomfort and inflammation caused by mild osteoarthritis.

How would I know if MetaboliX^® Plus is effective for me?

By taking MetaboliX^® Plus, it is an investment for your well-being as it works to improve the health of your cells. Bearing in mind that every individual’s physiology make-up is unique, some may experience a positive difference in energy level throughout the day within 3-4 weeks, while others may take longer.

Product Reviews (2)

Jack S, 50

I had to say goodbye to my golf clubs several years ago due to a persistent shoulder joint ache. It got so bad that whenever I wanted to turn to the side, I couldn’t do so by just turning my head. My wife suggested that I give MetaboliX Plus a try several months ago, and I felt a slight improvement within a day of consumption. By the 3rd day, I was able to turn my head without having to twist my shoulders along. MetaboliX Plus is now part of my daily diet and I am holding on to the hope of returning to the golf course one day!

William C, 60

I suffered from mild osteoarthritis in my feet, giving me pains when I used to walk for too long. Eventually, it got so bad that I had to give up golf and other sports. After taking MetaboliX Plus, I noticed that the pain started to lessen gradually within 3-5 days. Needless to say, I’m back to my active lifestyle! Thanks Entity!