FortefiX^® Plus

Product Information

We always take things for granted until we lose them; our mobility is one of them. Our musculoskeletal conditions determine our mobility. As a person ages, his bones and joints deteriorate, which leads to an array of chronic musculoskeletal disorders, e.g. osteoarthritis and osteoporosis. These disorders encompass chronic pain and physical disability, diminishing one’s quality of life¹.

COMBATS ARTHRITIS

Curcumin is a compound extracted from an Indian spice, turmeric (Curcumin longa). Curcumin has exhibited numerous therapeutic actions, including anti-inflammatory and anti-oxidant properties which contributes to its anti-arthritic attribute. Osteoarthritis is a degenerative joint disease which involves the retrogression of the cartilage, affecting the fluidity of joint motions. Curcumin decreases the production of certain inflammatory markers, reducing the pain associated with osteoarthritis. Also, it is found to suppress gene expression of several enzymes which are crucial in the degradation of the joint matrix^5,6,7.

PRESERVING THE JOINTS

The gum resin of Boswellia serrata comprises a high concentration of boswellic acids, which is known for its anti-inflammatory activity. Boswellic acids have been identified to inhibit 5-lipoxygenase, the key enzyme in the production of inflammatory mediators which are involved in the degradation of collagen and elastin found in the extracellular joint matrix. With such valuable properties, it is useful in impeding the development of osteoarthritis. Boswellic acids were proven in studies to alleviate pain and subsequently promoting physical activity and reducing limb stiffness^2,3,8.

BONE HEALTH AND MAINTENANCE

Boron is a trace element which serves as a micronutrient for the body. It possesses a diverse spectrum of benefits that are vital to human health. Boron is vital for the formation of bones and its deficiency has been proven to delay bone growth and regeneration. Boron increases the production of steroid hormones, which averts calcium loss and bone demineralization^1,9.

ALLEVIATE CARTILAGE DEGENERATION

The generation of pro-inflammatory cytokines and oxidative stress are hallmarks of inflammation¹⁰. In osteoarthritis, the increase in inflammatory mediators including chemokines, adipokines, and pro-inflammation cytokines (TNF-α, IL-1β, IL-4, and IL-6) leads to the destruction of cartilage¹¹. In addition, oxidative stress and reactive oxygen species (ROS) in osteoarthritis induce the death of an important cartilage component, chondrocytes¹¹. These effects result in the erosion and degeneration of articular cartilage in joints¹¹.
Resveratrol is a natural dietary compound found in blueberries, grapes, red and white wine etc. It reduces the expression of inflammatory mediators, oxidative stress and the production of reactive oxygen species (ROS) which ultimately alleviates cartilage degeneration¹¹.
Resveratrol was discovered earlier than pterostilbene (both produced by plants) and have more clinical studies and more clinical profiles/data than pterostilbene, hence it’s used in our new formulation.

Ingredients

Serving Size: 1-2 capsules
Servings Per Container: Up to 60
Amount Per Capsule:

Directions

How to use

Take 1-2 capsules daily with food or as recommended by your physician.

Storage

Store in cool, dry place. Keep out of reach of children. Use only if bottle is sealed.

Precautions

Do not take FortefiX^® Plus if you are pregnant, breastfeeding, trying to conceive or under 18 years of age.
If you have any medical conditions, please consult your physician prior to use.

Science

1. Palacios C. The Role of Nutrients in Bone Health, from A to Z. Critical Reviews in Food Science and Nutrition. 2006;46(8):621-628.
2. Sengupta K, Alluri K, Satish A, Mishra S, Golakoti T, Sarma K et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee. Arthritis Research & Therapy. 2008;10(4):R85.
3. Vetvicka V, Vetvickova J. Comparison of Anti-Inflammatory Effects of Boswellin. Journal of Nature and Science. 2016; 2(1):e172.
4. Cameron M1, Chrubasik S. Oral herbal therapies for treating osteoarthritis. Cochrane Database Systematic Reviews. 2014; 22(4):CD002947.
5. He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?. Molecules. 2015;20(5):9183-9213.
6. Woolf, A. and Pfleger, B. (2017). Burden of major musculoskeletal conditions. [online] Scielosp.org. Available at: http://www.scielosp.+H13:H16org/scielo.php?script=sci_arttext&pid=S0042-96862003000900007 [Accessed 13 Sep. 2017].
7. Rohanizadeh, R., Deng, Y. and Verron, E. (2017). Therapeutic actions of curcumin in bone disorders. [online] Bonekey Reports. Available at http://www.nature.com/bonekeyreports/2016/160302/bonekey201620/full/bonekey201620.html?foxtrotcallback=true [Accessed 13 Sep. 2017].
8. Akhtar, N. and Haqqi, T. (2017). Current nutraceuticals in the management of osteoarthritis: a review. [online] NCBI. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400101/ [Accessed 13 Sep. 2017].
9. Pizzorno, L. (2017). Nothing Boring About Boron. [online] NCBI. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/ [Accessed 13 Sep. 2017].
10. Goldring M, Otero M. Inflammation in osteoarthritis. Current Opinion in Rheumatology. 2011;23(5):471-478.
11. Xue E, Lin J, Zhang Y, Sheng S, Liu H, Zhou Y et al. Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Oncotarget. 2017;8(26):41988–42000.

FAQ

Who is FortefiX^® Plus suitable for?

FortefiX^® Plus is most suitable for men and women who:
– are experiencing stiffness and pain in their joints
– suffer from joint-related sport injuries
– wish to regain joint flexibility and improve mobility

When should I start taking FortefiX^® Plus?

While most people usually begin taking FortefiX^® Plus after experiencing some joint discomfort, it can be taken as a preventive measure to strengthen bones and keep joint inflammation at bay by athletes or adults approaching age 40.

Do I still need to continue taking vitamin D supplements and calcium-rich food when I’m on FortefiX^® Plus?

Yes. FortefiX^® Plus is not a replacement of Vitamin D supplements and a calcium-rich diet. It is important to get sufficient amounts of Vitamin D and calcium for healthy bones.

Product Reviews (1)

CT Teo, 61

Not sure about the effect of the anti-aging supplement (MetaboliX Plus) yet but the joint supplement (FortefiX Plus) seems to have some positive effect as the knee pain exacerbated by my long daily evening walks seems to have disappeared. So I am reordering both.